https://timeisbrain.org/ Recent content on The Time Is Brain Review Hugo -- gohugo.io en-us Tue, 13 Oct 2026 00:00:00 +0000 https://timeisbrain.org/10.1136-bmj-2025-085810/ Tue, 13 Oct 2026 00:00:00 +0000 https://timeisbrain.org/10.1136-bmj-2025-085810/ In a 77-hospital Chinese cluster-randomized trial, a multifaceted stroke decision-support system improved care-process measures and reduced 3-month vascular events, without a detected difference in disability or mortality. https://timeisbrain.org/10.1093-esj-aakag100/ Mon, 12 Oct 2026 00:00:00 +0000 https://timeisbrain.org/10.1093-esj-aakag100/ In pooled prospective cohorts, symptomatic carotid near-occlusion with full distal ICA collapse was associated with substantially higher recurrent-stroke risk in the first 48 hours, but the observational study does not establish benefit from revascularisation. https://timeisbrain.org/10.1016-j.eclinm.2026.103900/ Sun, 11 Oct 2026 00:00:00 +0000 https://timeisbrain.org/10.1016-j.eclinm.2026.103900/ In RICH-2, remote ischaemic conditioning improved day-7 haematoma imaging measures but did not improve the prespecified 90-day functional outcome. https://timeisbrain.org/10.1186-s42466-026-00539-8/ Sat, 10 Oct 2026 00:00:00 +0000 https://timeisbrain.org/10.1186-s42466-026-00539-8/ In a 200-patient retrospective transfer cohort, 9.5% had a repeat-imaging change affecting EVT eligibility, but the observed associations do not validate a triage rule. https://timeisbrain.org/10.1186-s13020-026-01501-1/ Fri, 09 Oct 2026 00:00:00 +0000 https://timeisbrain.org/10.1186-s13020-026-01501-1/ A single-center randomized trial found greater immediate naming-score improvement when scalp acupuncture was added to speech-language therapy, but the small per-protocol analysis, lack of sham control and unblinded treatment limit causal interpretation. https://timeisbrain.org/10.1093-esj-aakag055/ Thu, 08 Oct 2026 00:00:00 +0000 https://timeisbrain.org/10.1093-esj-aakag055/ A selected CT-based secondary analysis of TENSION links EVT with less 24-hour net water uptake and estimates an oedema-mediated pathway to 90-day outcome, but the mediation is hypothesis-generating. https://timeisbrain.org/10.1002-acn3.70542/ Wed, 07 Oct 2026 00:00:00 +0000 https://timeisbrain.org/10.1002-acn3.70542/ In a retrospective 27-center ESUS cohort, phenotypic clusters tracked prognosis but not differential anticoagulation response; LVEF and cancer history were exploratory effect-modifier signals. https://timeisbrain.org/10.1136-openhrt-2026-004393/ Tue, 06 Oct 2026 00:00:00 +0000 https://timeisbrain.org/10.1136-openhrt-2026-004393/ In a single-centre retrospective cohort, detected AF affected 30.5% of patients and clustered with stroke severity, prior stroke, cardiac disease and atrial-remodelling markers. https://timeisbrain.org/10.1093-esj-aakag001/ Mon, 05 Oct 2026 00:00:00 +0000 https://timeisbrain.org/10.1093-esj-aakag001/ In a preplanned ESTREL analysis, early levodopa/carbidopa did not reduce screen-defined depression at three months; selection and imprecision limit the conclusion. https://timeisbrain.org/10.1186-s12916-024-03820-2/ Sun, 04 Oct 2026 00:00:00 +0000 https://timeisbrain.org/10.1186-s12916-024-03820-2/ TRUST found no improvement in 90-day excellent functional outcome with one million units of intravenous urokinase versus guideline-based medical treatment for minor ischemic stroke within six hours; substantial crossover and sparse bleeding events limit stronger conclusions. https://timeisbrain.org/10.3390-medicina62091749/ Sat, 03 Oct 2026 00:00:00 +0000 https://timeisbrain.org/10.3390-medicina62091749/ In a small stroke rehabilitation trial, unstable-surface squats increased rectus femoris and vastus medialis thickness more than stable-surface squats, without establishing strength or functional benefit. https://timeisbrain.org/10.1371-journal.pone.0358740/ Fri, 02 Oct 2026 00:00:00 +0000 https://timeisbrain.org/10.1371-journal.pone.0358740/ A 40-patient trial found better four-week balance and lower-limb function when blood flow restriction was added to visual feedback training, but circulating biomarkers did not establish cerebral repair. https://timeisbrain.org/10.3389-fimmu.2025.1678840/ Wed, 30 Sep 2026 00:00:00 +0000 https://timeisbrain.org/10.3389-fimmu.2025.1678840/ An exploratory PHYS-STROKE biomarker analysis links baseline neuronal autoantibodies to selected six-month outcomes, but only the NMDAR–subjective mobility association survives correction for multiple comparisons. https://timeisbrain.org/10.1136-bmj-2025-086850/ Mon, 28 Sep 2026 00:00:00 +0000 https://timeisbrain.org/10.1136-bmj-2025-086850/ In selected Chinese patients with anterior-circulation large-vessel occlusion treated by thrombectomy, edaravone dexborneol produced a borderline increase in 90-day functional independence without a detected increase in serious adverse events. https://timeisbrain.org/10.1007-s12975-025-01404-7/ Sun, 27 Sep 2026 00:00:00 +0000 https://timeisbrain.org/10.1007-s12975-025-01404-7/ In a 36-person sham-controlled thrombectomy pilot, auricular vagus stimulation was feasible and showed no serious device-related harm, but did not reduce 24-hour systolic blood-pressure variability. https://timeisbrain.org/10.1186-s12984-026-02133-0/ Sat, 26 Sep 2026 00:00:00 +0000 https://timeisbrain.org/10.1186-s12984-026-02133-0/ In an under-enrolled, assessor-blinded trial, a soft robotic glove was not superior to supervised GRASP for upper-limb recovery after subacute stroke; a post-hoc distal-hand signal needs confirmation. https://timeisbrain.org/10.1093-esj-aakag111/ Thu, 24 Sep 2026 00:00:00 +0000 https://timeisbrain.org/10.1093-esj-aakag111/ Baseline occlusion status did not identify a minor-stroke subgroup with improved 90-day recovery after tenecteplase versus non-thrombolytic care in TEMPO-2. https://timeisbrain.org/10.1161-strokeaha.124.049834/ Wed, 23 Sep 2026 00:00:00 +0000 https://timeisbrain.org/10.1161-strokeaha.124.049834/ In a two-center randomized pilot, adding Cerebrolysin to speech therapy improved 90-day aphasia scores versus placebo plus speech therapy, but larger, longer-term trials are needed before routine use. https://timeisbrain.org/10.1212-wnl.0000000000218449/ Tue, 22 Sep 2026 00:00:00 +0000 https://timeisbrain.org/10.1212-wnl.0000000000218449/ Remote DWI-positive lesions occurred in 21.6% of patients with acute intracerebral hemorrhage and independently marked greater small-vessel-disease burden and worse six-month functional outcome. https://timeisbrain.org/10.1161-strokeaha.125.054101-v2/ Mon, 21 Sep 2026 00:00:00 +0000 https://timeisbrain.org/10.1161-strokeaha.125.054101-v2/ In this 48-participant randomized trial, adding action observation to virtual-reality rehabilitation produced a larger paretic-hand dexterity gain than virtual reality alone, exceeding the study’s 7-block smallest-detectable-difference benchmark at treatment end and persisting at 6 months. https://timeisbrain.org/10.1001-jamaneurol.2023.5200/ Sun, 20 Sep 2026 00:00:00 +0000 https://timeisbrain.org/10.1001-jamaneurol.2023.5200/ In 206 Japanese acute ischemic stroke patients, intravenous MultiStem given 18–36 hours after onset was safe but produced no overall benefit at 90 days; post-hoc signals hinted at efficacy in patients ≤64 years or with larger ischemic cores. https://timeisbrain.org/10.1161-strokeaha.126.055374/ Sat, 19 Sep 2026 00:00:00 +0000 https://timeisbrain.org/10.1161-strokeaha.126.055374/ Quantitative infarct volumetry — not NCCT-ASPECTS — sets the true ceiling for endovascular thrombectomy in large-core stroke: benefit holds up to a DWI core of roughly 110 mL, then collapses. https://timeisbrain.org/10.1001-jamaneurol.2024.1433/ Fri, 18 Sep 2026 00:00:00 +0000 https://timeisbrain.org/10.1001-jamaneurol.2024.1433/ In 6100 Chinese patients with mild ischemic stroke or high-risk TIA from presumed atherosclerosis, immediate-intensive atorvastatin (within 72 hours) did not reduce 90-day stroke recurrence versus a 3-day delayed start (8.1% vs 8.4%; HR 0.95; 95% CI 0.80-1.13; P = .58), with no excess bleeding — leaving functional outcome (OR 0.83) as hypothesis-generating. https://timeisbrain.org/10.1136-svn-2025-004547/ Thu, 17 Sep 2026 00:00:00 +0000 https://timeisbrain.org/10.1136-svn-2025-004547/ In a 235-patient Chinese RCT of fibrinogenase for injection within 72 hours of AIS onset, the ordinal mRS distribution at 90 days favoured fibrinogenase over placebo (OR 2.38, 95% CI 1.49–3.85; p<0.001), with no excess bleeding or mortality. https://timeisbrain.org/10.1161-strokeaha.125.053989/ Wed, 16 Sep 2026 00:00:00 +0000 https://timeisbrain.org/10.1161-strokeaha.125.053989/ In INTERACT3 surgical-evacuation patients, achieving systolic BP <140 mm Hg within 2 hours was associated with lower death or disability, better mRS shift, fewer serious adverse events, and no increase in mortality. https://timeisbrain.org/10.1161-circulationaha.125.074482/ Tue, 15 Sep 2026 00:00:00 +0000 https://timeisbrain.org/10.1161-circulationaha.125.074482/ In a prespecified substudy of the 17,604-patient SELECT trial, semaglutide reduced hsCRP by 37.8% at 104 weeks — an effect independent of weight loss — and a 25% lower baseline hsCRP tracked a 8% lower MACE risk; hsCRP lowering explains only a fraction of the 20% MACE reduction. https://timeisbrain.org/10.3389-fneur.2025.1715049/ Mon, 14 Sep 2026 00:00:00 +0000 https://timeisbrain.org/10.3389-fneur.2025.1715049/ In this meta-analysis of 2,054 LVO patients across five RCTs, IV tenecteplase improved functional outcomes versus no thrombolysis, with a clear win for bridging within 4.5 hours before EVT and for extended-window use without EVT — but no benefit (and possible harm) for bridging between 4.5 and 24 hours. https://timeisbrain.org/10.1161-strokeaha.124.049715/ Sun, 13 Sep 2026 00:00:00 +0000 https://timeisbrain.org/10.1161-strokeaha.124.049715/ ProFATE: temporary proximal blood flow arrest via balloon guide catheter during anterior-circulation thrombectomy did not significantly improve eTICI 2c/3 (74.4% vs 70.8%; aOR 1.07, P=0.88) but reduced distal embolization (1.5% vs 12.3%) and tripled first-pass complete recanalization (33% vs 15.3%) in 131 patients across four UK centers. https://timeisbrain.org/10.1161-strokeaha.125.051532/ Sat, 12 Sep 2026 00:00:00 +0000 https://timeisbrain.org/10.1161-strokeaha.125.051532/ In a multicenter preclinical RCT of remote ischemic conditioning in 164 rodents across 7 labs, RIC-treated animals were more likely to achieve a good functional outcome at 48 hours (55% vs 36%; OR 2.2, 95% CI 1.23–4.4, P=0.009). https://timeisbrain.org/10.1161-strokeaha.125.050729/ Fri, 11 Sep 2026 00:00:00 +0000 https://timeisbrain.org/10.1161-strokeaha.125.050729/ Liberal transfusion (Hb <9 g/dL) trended toward less unfavorable neurological outcome at 180 days than restrictive (Hb <7 g/dL) in anemic ICH patients, but the difference did not reach significance (RR 0.85, 95% CI 0.71-1.01, P=0.06). https://timeisbrain.org/10.1001-jamaneurol.2025.2036/ Thu, 10 Sep 2026 00:00:00 +0000 https://timeisbrain.org/10.1001-jamaneurol.2025.2036/ DATE: adjunctive intra-arterial tenecteplase at 0.0313 or 0.0625 mg/kg after successful reperfusion is safe to advance to a phase 3 trial, with a numerically higher but non-significant 90-day no-disability rate (43.5% vs 33.8% control). https://timeisbrain.org/10.1161-jaha.125.043268/ Wed, 09 Sep 2026 00:00:00 +0000 https://timeisbrain.org/10.1161-jaha.125.043268/ In a Danish nationwide cohort of 5,800 patients with intracerebral hemorrhage receiving antiplatelet therapy, prior dual therapy was associated with higher early mortality than single therapy, with a weighted risk ratio of 1.43 by day 1. https://timeisbrain.org/10.1212-wnl.0000000000218354/ Tue, 08 Sep 2026 00:00:00 +0000 https://timeisbrain.org/10.1212-wnl.0000000000218354/ In a cross-sectional cohort, probable cerebral amyloid angiopathy was associated with substantially more depressive symptoms and poorer cognition, but depression explained only a small fraction of the cognitive association. https://timeisbrain.org/10.1177-17562864261476124/ Mon, 07 Sep 2026 00:00:00 +0000 https://timeisbrain.org/10.1177-17562864261476124/ Clinical Question (PICO) In adults aged 18–65 years at least 2 weeks after ischemic or hemorrhagic stroke, with stable vital signs and unilateral motor dysfunction affecting the upper and lower limbs (P), does bilateral transcutaneous auricular nerve stimulation (BtaNS) added to standardized rehabilitation (I), compared with left-sided stimulation (LtaNS) or sham stimulation (C), improve upper- and lower-limb motor function, balance, and activities of daily living through 8 weeks after treatment (O)? https://timeisbrain.org/10.1136-jnis-2025-023132/ Mon, 07 Sep 2026 00:00:00 +0000 https://timeisbrain.org/10.1136-jnis-2025-023132/ In a retrospective four-center series of 102 distal medium vessel occlusions treated with the RED 43 catheter, final reperfusion was achieved in 83% of primary and 87% of secondary DMVOs, while 57% achieved functional independence at 3 months; the absence of a medical-therapy comparator prevents causal claims. https://timeisbrain.org/10.1001-jamaneurol.2026.1706/ Sun, 06 Sep 2026 00:00:00 +0000 https://timeisbrain.org/10.1001-jamaneurol.2026.1706/ In the HOPE randomized trial, reperfusion-guided systolic blood-pressure targets after thrombectomy increased 90-day functional independence from 47.1% to 60.0% without increasing symptomatic intracranial hemorrhage or mortality. https://timeisbrain.org/10.1371-journal.pone.0355300/ Sat, 05 Sep 2026 00:00:00 +0000 https://timeisbrain.org/10.1371-journal.pone.0355300/ In 419 patients younger than 50 years treated at one UAE hospital, hypertension and diabetes were common, nearly half of ischemic strokes remained of undetermined cause, and in-hospital mortality was 12.68%. https://timeisbrain.org/10.1111-1460-6984.70295/ Fri, 04 Sep 2026 00:00:00 +0000 https://timeisbrain.org/10.1111-1460-6984.70295/ An ethnographic study of 10 acute-stroke patients shows that dysphagia plans are often only partially enacted, making communication, mealtime preparation, oral care, and reliable resources central targets for preventing stroke-associated pneumonia. https://timeisbrain.org/10.1136-bmjno-2026-001727/ Thu, 03 Sep 2026 00:00:00 +0000 https://timeisbrain.org/10.1136-bmjno-2026-001727/ In the first 758 participants of the BeLOVE stroke cohort, 2-year cumulative incidence was 10.7% for major adverse cerebrovascular and cardiovascular events, with ischemic stroke the most common component. https://timeisbrain.org/10.1016-s1474-44222400369-7/ Tue, 01 Sep 2026 00:00:00 +0000 https://timeisbrain.org/10.1016-s1474-44222400369-7/ GBD 2021 estimates 11.9 million incident strokes (95% UI 10.7-13.2), 7.3 million deaths, 93.8 million prevalent cases, and 160.5 million DALYs in 2021, with 84.1% of stroke DALYs (135.0 million) attributable to 23 risk factors — high systolic blood pressure (56.8% PAF) and ambient particulate matter (16.6%) leading. https://timeisbrain.org/10.1186-s12987-026-00798-2/ Mon, 31 Aug 2026 00:00:00 +0000 https://timeisbrain.org/10.1186-s12987-026-00798-2/ In a thromboembolic rat stroke model, the 35 kDa claudin-5 isoform 1 transiently rises in ipsilateral cerebrovasculature at 6 h and correlates with 24-hour cerebral edema, neurological deficit, and hemorrhagic transformation but not with infarct volume. https://timeisbrain.org/10.1161-strokeaha.125.054555/ Sun, 30 Aug 2026 00:00:00 +0000 https://timeisbrain.org/10.1161-strokeaha.125.054555/ In a longitudinal Oxford cohort, most survivors showed cognitive recovery after stroke—mainly in the first 6 months—but acute cognitive burden strongly predicted persistent deficits, and a small subgroup declined over time. https://timeisbrain.org/10.1161-strokeaha.125.054101/ Thu, 27 Aug 2026 00:00:00 +0000 https://timeisbrain.org/10.1161-strokeaha.125.054101/ Clinical Question (PICO) In adults with poststroke hemiplegia and residual unilateral upper-limb movement 3 to 18 months after the acute event (P), does 5 weeks of action observation immediately followed by imitation-based virtual-reality motor training (AO+VR) (I), compared with the same virtual-reality motor training preceded by neutral nature videos (control observation plus VR, CO+VR) (C), improve paretic-hand dexterity and broader motor and functional outcomes at treatment completion and 6 months (O)? https://timeisbrain.org/10.1161-strokeaha.125.054738/ Wed, 26 Aug 2026 00:00:00 +0000 https://timeisbrain.org/10.1161-strokeaha.125.054738/ In 4,765 patients receiving oral antithrombotic therapy, severe MRI-defined cerebral small vessel disease was associated with functional decline over 24 months even after accounting for major bleeding and ischemic events. https://timeisbrain.org/10.1001-jamaneurol.2025.3151/ Sat, 22 Aug 2026 00:00:00 +0000 https://timeisbrain.org/10.1001-jamaneurol.2025.3151/ In the MIND trial, minimally invasive surgery with the Artemis device within 72 hours did not significantly reduce 30-day mortality or improve 180-day disability in supratentorial ICH versus medical management alone. https://timeisbrain.org/about/ Fri, 21 Aug 2026 00:00:00 +0000 https://timeisbrain.org/about/ The Time Is Brain Review is an independent medical-education publication focused on stroke neurology literature. Each article summarizes a published study and places its findings in clinical and methodological context. https://timeisbrain.org/10.1001-jamaneurol.2023.5093/ Fri, 21 Aug 2026 00:00:00 +0000 https://timeisbrain.org/10.1001-jamaneurol.2023.5093/ In 601 Chinese AIS patients with early neurological deterioration, 7-day argatroban + antiplatelet improved 90-d mRS 0–3 (80.5% vs 73.3%, aRR 1.10, P=0.03) without increased sICH (0.9% vs 0.7%). https://timeisbrain.org/10.5853-jos.2025.05386/ Fri, 21 Aug 2026 00:00:00 +0000 https://timeisbrain.org/10.5853-jos.2025.05386/ In a matched multicenter cohort of 746 large-vessel-occlusion patients undergoing bridging therapy, tenecteplase produced nearly twice the thrombus migration of alteplase (19.3% vs 11.3%), concentrated in the first 60 minutes after IVT, and migration independently predicted functional independence. https://timeisbrain.org/welcome/ Fri, 21 Aug 2026 00:00:00 +0000 https://timeisbrain.org/welcome/ Site move in progress. https://timeisbrain.org/deep-dive-andexanet-iche-annexa-i-secondary-analyses/ Thu, 20 Aug 2026 00:00:00 +0000 https://timeisbrain.org/deep-dive-andexanet-iche-annexa-i-secondary-analyses/ Shorter onset-to-treatment time, larger baseline hematoma volume, higher diastolic BP, and higher prescan growth rate predict HE but not thrombotic events in FXa-inhibitor ICH; andexanet benefit is amplified in the highest-risk quartiles (NNT ~4). https://timeisbrain.org/deep-dive-argatroban-dapt-branch-atherosclerosis-bad-rct/ Wed, 19 Aug 2026 00:00:00 +0000 https://timeisbrain.org/deep-dive-argatroban-dapt-branch-atherosclerosis-bad-rct/ In 100 Chinese BAD patients with mild stroke, argatroban+DAPT cut early neurological deterioration from 47.1% to 20.4% (RR 2.31, P=0.006) and improved 90-day mRS 0–1 from 68.6% to 87.8% (P=0.025). https://timeisbrain.org/deep-dive-jx10-tms007-late-window-thrombolytic/ Tue, 18 Aug 2026 00:00:00 +0000 https://timeisbrain.org/deep-dive-jx10-tms007-late-window-thrombolytic/ Phase 2a dose-escalation: JX10 (TMS-007) given 5–12 hours post-LKN had 0% symptomatic ICH vs 2.6% placebo, with a day-90 mRS 0–1 of 40.4% vs 18.4% (P=0.03). https://timeisbrain.org/deep-dive-annexa-i-biomarker-substudy/ Mon, 17 Aug 2026 00:00:00 +0000 https://timeisbrain.org/deep-dive-annexa-i-biomarker-substudy/ Andexanet cuts anti-FXa activity and raises ETP at 1 hour; both biomarkers independently predict hematoma reduction but ETP rise also predicts more thrombotic events — the therapeutic window is 1 hour, and it cuts both ways. https://timeisbrain.org/deep-dive-perforator-territory-infarction-functional-outcome-lvo-stroke-2025/ Sun, 16 Aug 2026 00:00:00 +0000 https://timeisbrain.org/deep-dive-perforator-territory-infarction-functional-outcome-lvo-stroke-2025/ In 397 LVO thrombectomy patients (CONTRAST cohort), perforator-territory infarction on post-treatment MRI roughly tripled the odds of worse 90-day mRS (common OR 2.94, 95% CI 1.73–4.98) without significantly worsening 24-h NIHSS. https://timeisbrain.org/deep-dive-mrclean-m2-bridging/ Sat, 15 Aug 2026 00:00:00 +0000 https://timeisbrain.org/deep-dive-mrclean-m2-bridging/ In 539 Dutch M2 occlusion patients (2014–2018), IVT+EVT vs direct EVT produced better 90-day ordinal mRS (adjusted cOR 1.52, 95% CI 1.04–2.21, P=0.03) without significantly different sICH or recanalization rates. https://timeisbrain.org/deep-dive-etlas2-tadalafil-csvd-2026-08/ Fri, 14 Aug 2026 00:00:00 +0000 https://timeisbrain.org/deep-dive-etlas2-tadalafil-csvd-2026-08/ In 76 Danish CSVD patients, 3 months of tadalafil 20 mg/day did NOT meet the prespecified ≥90% compliance feasibility threshold (68% vs 94% placebo, OR 0.13, P=0.030), with markedly more AEs (76% vs 36%); a per-protocol WMH volume trend (P=0.054) hints at mechanistic activity. https://timeisbrain.org/optimas-2026-early-vs-delayed-anticoagulation/ Fri, 14 Aug 2026 00:00:00 +0000 https://timeisbrain.org/optimas-2026-early-vs-delayed-anticoagulation/ OPTIMAS subgroup analysis: in 3,619 stroke patients with AF, neither the time of AF diagnosis (before vs. after the index stroke) nor AF subtype (persistent vs. paroxysmal) modifies the effect of early DOAC initiation versus delayed initiation. Persistent AF is independently associated with roughly double the risk of recurrent ischemic stroke compared with paroxysmal AF. https://timeisbrain.org/deep-dive-zodiac-head-of-bed-thrombectomy/ Wed, 12 Aug 2026 00:00:00 +0000 https://timeisbrain.org/deep-dive-zodiac-head-of-bed-thrombectomy/ ZODIAC stopped at 92 patients (planned 182) after 0° head-of-bed positioning cut pre-thrombectomy END (≥2 NIHSS) from 55% to 2% (HR 34.40, P<0.001); exploratory mortality 4.4% vs 21.7% (P=0.03). https://timeisbrain.org/deep-dive-t-flavor-standard-dose-tenecteplase-vs-low-dose-alteplase/ Tue, 11 Aug 2026 00:00:00 +0000 https://timeisbrain.org/deep-dive-t-flavor-standard-dose-tenecteplase-vs-low-dose-alteplase/ T-FLAVOR (n=218): tenecteplase 0.25 mg/kg doubled pre-thrombectomy substantial reperfusion vs alteplase 0.6 mg/kg (10.3% vs 3.6%; 90% CI 0.89–12.1), meeting phase-2 surrogate threshold despite the conventional 95% CI crossing zero. https://timeisbrain.org/actisave-glenzocimab-thrombolysis-thrombectomy/ Mon, 10 Aug 2026 00:00:00 +0000 https://timeisbrain.org/actisave-glenzocimab-thrombolysis-thrombectomy/ ACTISAVE failed to confirm a beneficial effect of glenzocimab on mRS in patients with acute ischemic stroke treated by thrombolysis https://timeisbrain.org/cr-interval-poststroke-fatigue-rehab/ Mon, 10 Aug 2026 00:00:00 +0000 https://timeisbrain.org/cr-interval-poststroke-fatigue-rehab/ In a 2-center PROBE RCT (n=43 completers), 8 weeks of home-based supervised HIIT cut poststroke fatigue by 5.35 S-FAS points (95% CI -9.03 to -3.67) and improved VO2peak by 4.48 mL/kg/min. https://timeisbrain.org/lamp-liraglutide-stroke-insulin-resistance/ Mon, 10 Aug 2026 00:00:00 +0000 https://timeisbrain.org/lamp-liraglutide-stroke-insulin-resistance/ In LAMP post-hoc analysis, liraglutide reduced 90-day recurrent stroke from 18.1% to 5.8% (HR 0.30, NNT 8) in patients with HOMA-IR ≥ 2.5; no benefit in patients with preserved insulin sensitivity.