Cerebral-Small-Vessel-Disease
DWI-Positive Lesions in Patients With Acute Intracerebral Hemorrhage — Associations With Cerebral Small Vessel Disease and Clinical Outcome
Remote DWI-positive lesions occurred in 21.6% of patients with acute intracerebral hemorrhage and independently marked greater small-vessel-disease burden and worse six-month functional outcome.
Impact of Cerebral Small Vessel Disease on Functional Decline: Bleeding With Antithrombotic Therapy 2 Study
In 4,765 patients receiving oral antithrombotic therapy, severe MRI-defined cerebral small vessel disease was associated with functional decline over 24 months even after accounting for major bleeding and ischemic events.
Deep-Dive: ETLAS-2 — Tadalafil for CSVD Fails Feasibility, but the Imaging Signal Hints at a Better Trial
ETLAS-2 phase II: tadalafil 20 mg daily for 3 months in CSVD fails feasibility (compliance 68% vs 94% placebo) with 2-fold more AEs; per-protocol WMH volume trend suggests mechanistic signal at lower doses.